The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes

► A new model of TCR signaling downmodulation mediated by CD5 is proposed. ► The C-terminal region of CD5 appears to be crucial for TCR-mediated downregulation. ► The mechanism relies in the recruitment of p-c-Cbl to the C-terminal region of CD5. ► Activation of associated p-c-Cbl results in degradation of downstream target Vav.