PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion

► Growth of cancer cells were significantly retarded by PRMT6 overexpression. ► Migration and invasion was strongly suppressed by PRMT6 overexpression. ► These suppressions are closely associated with TSP-1 induction by PRMT6. ► PRMT6 overexpression down-regulates MMP expression in cancer cells.