Novel cell penetrating peptides with multiple motifs composed of RGD and its analogs

► Peptides with multiple motifs composed of RGD and its analogs induce liposome uptake into most cells. ► The peptides shows no cytotoxicity at 100 μM. ► The internalized liposome encapsulating siRNA induce the siRNA-mediated gene silencing. ► The peptide with the motifs are considered as a new type of cell penetrating peptide.