Role of CXCR2 on the immune modulating activity of α-iso-cubebenol a natural compound isolated from the Schisandra chinensis fruit

► α-Iso-cubebenol stimulated cellular calcium increase in human neutrophils. ► α-Iso-cubebenol enhanced degranulation activity in neutrophils. ► α-Iso-cubebenol stimulated neutrophil chemotactic migration via CXCR2. ► α-Iso-cubebenol showed anti-septic activity via CXCR2. ► The finding suggests α-iso-cubebenol and CXCR2 as therapeutic approach to treat sepsis.