Ivabradine inhibits the production of proinflammatory cytokines and inducible nitric oxide synthase in acute coxsackievirus B3-induced myocarditis

► Ivabradine effectively reduces myocardial inflammation and fibrosis in myocarditis. ► Ivabradine reduces the production of nitric oxide and inducible NO synthase in myocarditis. ► Ivabradine inhibits the levels of TNF-α and IL-6 in viral myocarditis.