Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation

► We hypothesize that neurodegeneration in anti-NGF is due to NGF/proNGF imbalance. ► We propose that the proNGF co- receptor sortilin contributes to the neurodegeneration. ► We analyzed anti-NGF mice crossed to sortilin knockout mice. ► Sortilin loss partially protected AD10 anti-NGF mice from neurodegeneration.