Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism

► TGF-β1 transcriptionally increases expression of the Angptl2 gene. ► We identified specific Smad Binding Element (SBE) within Angptl2 promoter. ► TGF-β1-mediated induction of Angptl2 gene requires Smad3. ► This is the first report about a connection between TGF-β signaling and Angptl2 gene.