Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family

► Lipasin is a novel but atypical member of the ANGPTL family. ► Lipasin, ANGPTL1, 2 and 4 are abundant in brown fat. ► Cold exposure increases Lipasin, but reduces ANGPTL4 in BAT. ► Fasting reduces Lipasin but increases ANGPTL4 in BAT. ► ANGPTL2 is both thermoregulated and nutritionally regulated in BAT.