Aβ1-42 disrupts the expression and function of KLF2 in Alzheimer's disease mediated by p53

► First time to show the reduced KLF2 level in AD transgenic mice. ► First time to show Aβ1-42 disrupts the expression of KLF2. ► Overexpression of KLF2 rescued impaired expression of Occludin induced by Aβ. ► p53 mediated impaired expression and function of KLF2 induced by Aβ. ► Suggesting the role of KLF2 in impaired brain blood barrier in AD.