Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma

► MK886 sensitizes glioma cells to TRAIL-mediated apoptosis via upregulation of DR5. ► Upregulation of DR5 induced by MK886 is regulated by p38 MAPK. ► Knockdown of p38 MAPK blocks DR5 upregulation and TRAIL-induced apoptosis. ► MK886-induced TRAIL sensitization is independent of ROS.