Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model

► We construct a cell permeable Tat-GLO protein. ► We examined the protective effects of Tat-GLO protein on SNP-induced cell death. ► Transduced Tat-GLO protein protects from the STZ-induced pancreas tissue. ► Tat-GLO protein markedly reduced STZ-induced blood glucose levels. ► Tat-GLO protein could be useful as a therapeutic agent for diabetes.