Reduced expression of NLRP3 and MEFV in human ischemic heart tissue

► The NLRP3 inflammasome displayed decreased levels in human ischemic heart. ► We observed reduced mRNA levels of MEFV in ischemic heart tissue. ► Genetic analysis showed mutations in NLRP3 and MEFV only in ischemic heart tissue. ► Low expression of NLRP3 and MEFV may have a role in a defective immune response. ► Defects in the inflammasome may be involved in promoting ischemic heart disease.