Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via β-catenin upregulation

► We studied expression of ILK, PINCH, parvin, Mig2 and Migfilin in osteoarthritis. ► We show that ILK and Migfilin were upregulated in osteoarthritic chondrocytes. ► We show for the first time that migfilin silencing exacerbates osteoarthritis. ► We provide a link between migfilin and β-catenin activation in OA chondrocytes. ► In osteoarthritic chondrocytes migfilin is inversely correlated with β-catenin.