c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α

► We investigated the role of c-Myc in tumor angiogenesis. ► c-Myc regulated HIF-1α at the post-transcriptional level. ► We firstly found c-Myc-dependent regulation of HIF-1α. ► c-Myc enhanced angiogenesis through the HIF-1α/VEGF pathway.