Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy

► Zerumbone insolubilized cellular proteins in vitro. ► Zerumbone induced ubiquitination and aggregation of cellular proteins. ► Zerumbone activated the ubiquitin-proteasome system and autophagy. ► Zerumbone conferred resistance to toxicity of 4-hydroxy-2-nonenal via p62 induction.