Angiotensin-(1-7) regulates Angiotensin II-induced VCAM-1 expression on vascular endothelial cells

► We for the first time found that Ang-(1-7) inhibits Ang II-induced VCAM-1 expression. ► The inhibitory effect of Ang-(1-7) on VCAM-1 is mediated by MAS receptor. ► The effect of Ang-(1-7) is due to the suppression of NF-kappaB translocation.