The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence

► Stm1p confers increased resistance to the macrolide starvation-mimic rapamycin. ► Stm1p maintains 80S ribosome integrity during stationary phase-induced quiescence. ► Stm1p facilitates polysome formation following quiescence exit. ► Stm1p facilitates protein synthesis following quiescence exit. ► Stm1p is a ribosome preservation factor under conditions of nutrient deprivation.