Requirement for both receptor-operated and store-operated calcium entry in N-formyl-methionine-leucine-phenylalanine-induced neutrophil polarization

► SOCE inhibition could not abrogate fMLP-induced Ca2+ entry completely. ► Neither Rac2 nor Cdc42 activation could take place if either SOCE or ROCE was inhibited. ► Both SOCE and ROCE involved in fMLP-induced neutrophil polarization.