Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus

► Forced swim (FS) induces changes in the phosphorylation of proteins in the brain. ► Water temperature is a key determinant of the effects of FS. ► Phosphorylation states of CaMKII and SIRPα are primarily affected by hypothermia. ► Hypothermia does not affect the levels of phosphorylation of MEK and CREB. ► Brain responds to the FS stress in a hypothermia-dependent and -independent manner.