The large conductance calcium-activated K+ channel interacts with the small GTPase Rab11b

► We show the interaction of Rab11b and the BK channel in cochlea. ► We reveal that BK and Rab11b colocalize in the cochlea. ► We demonstrate that BK expression increases with an increase in Rab11b. ► We demonstrate that BK expression decreases with Rab11b knockdown. ► We reveal that Rab11b interacts with the core region of the BK channel.