S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection

► Direct antiviral effect of purified Surface layer protein (S-layer) of Lactobacillus acidophilus. ► Inhibition of infection by Junin Virus that is mediated by DC-sign lectin. ► Basic nature of the S-layer is involved in the interaction with the viral receptor. ► Novel functionality for the S-layer not previously described including Carbohydrate recognition. ► Results support the probiotic status described for this lactobacilli strain.