Sodium arsenite down-regulates the expression of X-linked inhibitor of apoptosis protein via translational and post-translational mechanisms in hepatocellular carcinoma

► Sodium arsenite down-regulates the protein expression level of XIAP in HCC. ► Sodium arsenite inhibits the de novo XIAP synthesis and its IRES activity. ► Sodium arsenite decreases XIAP stability and promotes its proteasomal degradation. ► Overexpression of XIAP attenuates the pro-apoptotic effect of sodium arsenite.