CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

► CITED2 mutant decreased its ability to mediate the expression of VEGF and PITX2C. ► CITED2 mutant disrupt its competitiveness with HIF-1α for binding to CBP/p300. ► CITED2 mutant decreased cooperation between CITED2 and TFAP2C.