Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation

► We examined the effect of GLP-1 on macrophage activation in this study. ► GLP-1 induces STAT3 activation in human macrophages. ► GLP-1 induces macrophages differentiation toward the M2 phenotype. ► GLP-1-treated macrophages increase adiponectin secretion from adipocytes.