Effects of N-n-butyl haloperidol iodide on the rat myocardial sarcoplasmic reticulum Ca2+-ATPase during ischemia/reperfusion

► Short-term myocardial ischemia/reperfusion caused the decrease in SERCA activity. ► Short-term myocardial ischemia/reperfusion did not change SERCA2a protein levels. ► N-n-butyl haloperidol iodide protects SERCA activity after ischemia/reperfusion. ► N-n-butyl haloperidol iodide maintains intracellular Ca2+ homeostasis.