IP3-dependent intracellular Ca2+ release is required for cAMP-induced c-fos expression in hippocampal neurons

► cAMP-induced c-fos expression in hippocampal neurons requires a submembraneous Ca2+ pool. ► The submembraneous Ca2+ pool derives from intracellular ER stores. ► Expression of IP3-metabolizing enzymes inhibits cAMP-induced c-fos expression. ► SRE-mediated and CRE-mediated gene expression is sensitive to IP3-metabolizing enzymes. ► Intracellular Ca2+ release is required for cAMP-induced nuclear translocation of TORC1.