Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell

► miR-130a levels were significantly increased after cisplatin treatment. ► Upregulated miR-130a contributed to cisplatin resistance in Huh7 cell. ► Activation of Wnt signaling was increased after cisplatin treatment. ► Cisplatin-induced miR-130a increases drug resistance by regulating RUNX3 and Wnt.