Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

► Vascular endothelial insulin/IGF-1 signaling not essential for vascular skin homeostasis. ► Wound neo-angiogenesis is strongly reduced upon loss of vascular insulin/IGF-1 receptors. ► Endothelial Insulin resistance can directly contribute to diabetic foot ulcers. ► Potential for treatment of this important economic and health problem.