Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression

► Inflammation by Barrett's esophagus (BE) is a risk factor of its adenocarcinoma (BEA). ► 8-Nitroguanine and 8-oxodG are inflammation-related DNA lesions. ► DNA lesions and iNOS expression were higher in the order, BEA > BE > normal tissues. ► Proton pump inhibitors suppress DNA damage by increasing Mn-SOD via Nrf2 activation. ► DNA lesions can be useful biomarkers to predict risk of BEA in BE patients.