Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer

► Twist1 is a transcriptional repressor of claudin-4 in esophageal cancer. ► Twist1 binds to a proximal E-box site on the claudin-4 promoter. ► Twist1 and claudin-4 are inversely correlated in esophageal cancer tissues.