Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression

► 56 Corepressor recruitment restrains AR in androgen-dependent CaP. ► 51 Androgens promote SMRT corepressor recruitment to AR in CaP. ► 58 Loss of SMRT results in increased AR activity in androgen-resistant CaP. ► 59 Coactivators increase AR activity in androgen-resistant CaP. ► 56 Loss of SMRT is consistent with loss of normal function for AR in CaP.