Elevated glucagon-like peptide-1 plasma levels, as a possible adaptive response, in diabetic NOD mice

► Increased plasma total GLP-1 in diabetic, compared to non diabetic, NOD mice. ► Greater GLP-1 response to OGTT in diabetic, compared to non diabetic, NOD mice. ► Increased islet GLP-1 staining in diabetic, compared to non diabetic, NOD mice. ► Upregulation of GLP-1 may be a novel defense mechanism against diabetes.