WT1 CpG islands methylation in human lung cancer: A pilot study

► Hypermethylation of gene promoters is linked to carcinogenesis. ► Wilm's tumor (WT1) gene is involved in K Ras signaling and lung cancer cell growth. ► Methylation of 29 CpG islands in WT1 5′ region was assessed in 16 NSCLC pts. ► WT1 gene methylation is significantly increased in NSCLC.