An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

► A Src-PDGFRA-Raf-Mapk axis mediates TKI resistance in rhabdomyosarcoma (RMS). ► Combined inhibition of Pdgfra and Src had additive effect on resistant cell viability. ► Sorafenib halted progression of mouse alveolar rhabdomyosarcoma tumors in vivo.