ANG-(1-7) reduces ANG II-induced insulin resistance by enhancing Akt phosphorylation via a Mas receptor-dependent mechanism in rat skeletal muscle

► ANG-(1-7) in vitro ameliorates ANG II-induced insulin resistance in rat skeletal muscle. ► This beneficial effect of ANG-(1-7) is associated with enhanced Akt Ser473 phosphorylation. ► The beneficial effects of ANG-(1-7) can be prevented by the Mas receptor antagonist A779. ► The results support targeting the renin-angiotensin system in insulin-resistant muscle.