Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates postincisional pain by regulating macrophage polarization

► Rosiglitazone attenuated postincisional pain. ► Rosiglitazone alters macrophage polarization to F4/80+CD206+ M2 macrophages at the incisional sites. ► Transplantation of rosiglitazone-treated macrophages produced analgesic effects.