Glycogen synthase kinase 3-β phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization

► Novel S/T-P-S/T domains were identified in NICD. ► Phosphorylation of NICD on the S/T-P-S/T domains induced nuclear localization. ► GSK-3β phosphorylated S and T residues in NICD S/T-P-S/T domains.