ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells

► LXR agonists, either TO901317 or GW3965, significantly enhance ABCA1 expression. ► TO901317 alone could significantly inhibit apoM expression. ► GW3965 alone did not influence apoM expression. ► Different effects of TO901317 and GW3965 on apoM expression relates to ABCA1. ► ABCA1 activation could upregulate apoM expression in HepG2 cells.