Molecular analysis of the TMPRSS3 gene in Moroccan families with non-syndromic hearing loss

► Sensorineural hearing loss is the most prevalent human genetic sensory defect. ► Mutations in the TMPRSS3 cause two forms of non-syndromic recessive deafness. ► We performed a genetic analysis of TMPRSS3 gene in 80 Moroccan deaf families. ► Nineteen variants were found which six are missense and three are synonymous. ► TMPRSS3 can be a contributor of hearing loss in the Moroccan population.