Anti-inflammatory effects of Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma

► We construct a cell permeable Tat-ANX1 fusion protein. ► We examined the protective effects of Tat-ANX1 protein on OVA-induced asthma in animal models. ► Transduced Tat-ANX1 protein protects from the OVA-induced production of cytokines and eosinophils in BAL fluid. ► Tat-ANX1 protein markedly reduced OVA-induced MAPK in lung tissues. ► Tat-ANX1 protein could be useful as a therapeutic agent for lung disorders including asthma.