Uridine adenosine tetraphosphate (Up4A) is a strong inductor of smooth muscle cell migration via activation of the P2Y2 receptor and cross-communication to the PDGF receptor

► Up4A induces VSMC migration. ► VSMC migration towards Up4A involves P2Y2 activation. ► Up4A-induced VSMC migration is OPN-dependent. ► Activation of ERK1/2 pathway is necessary for VSMC migration towards Up4A. ► Up4A-directed VSMC migration cross-communicates with the PDGFR.