Statins inhibit expression of Thioredoxin reductase 1 in rat and human liver and reduce tumour development

► Statins inhibits expression of Thioredoxin reductase 1 in rat and human liver tissue. ► Statin-mediated inhibition of Thioredoxin reductases may explain anti-carcinogenic effects of statins. ► Statin-mediated inhibition of Thioredoxin reductases may also explain other side-effects of statins.