Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene

► Lmo2 expression is elevated in Lck-transformed cells. ► Both endogenous and exogenous Lck localize in the nucleus. ► Nuclear Lck is active in Lck-transformed cells. ► Lck binds to the promoter region of Lmo2 gene in vivo. ► In contrast to JAK2, Lck does not increase histone H3 phosphorylation on Tyr 41.