Expression of prohibitins on the surface of activated T cells

► Prohibitin-1 and -2 were highly expressed on the surface of activated T cells. ► Cell surface prohibitins were co-localized with CD3 on the surface of Jurkat cells. ► In Jurkat cells, treatment with anti-prohibitin-1 and -2 antibodies inhibited anti-CD3 antibody-induced signaling.