C57BL/6JRj mice are protected against diet induced obesity (DIO)

► Identification of diet induced obesity protected BL/6 (BL/6JRj) substrain. ► Protection was independent from food intake. ► Relative fat mass was significantly increased only in BL/6NTac under high fat diet conditions. ► Identification of 11 SNP differences between both BL/6 substrains.