کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10761939 | 1050482 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells](/preview/png/10761939.png)
چکیده انگلیسی
⺠Mechanical stimulation is an important factor for regulation of stem cell fate. ⺠Cyclic stretch to human induced pluripotent stem cells activated small GTPase Rho. ⺠Rho-kinase activation attenuated pluripotency via inhibition of AKT activation. ⺠This reaction could be reproduced only by transfection of dominant active Rho. ⺠Rho/ROCK are important molecules in mechanotransduction and control of stemness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 417, Issue 2, 13 January 2012, Pages 836-841
Journal: Biochemical and Biophysical Research Communications - Volume 417, Issue 2, 13 January 2012, Pages 836-841
نویسندگان
Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Koichi Nakagawa, Chiaki Hamanishi, Kanji Fukuda,