NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model

► NOSH-aspirin is the first dual acting NO and H2S releasing hybrid. ► Its IC50 for cell growth inhibition is in the low nano-molar range. ► Structure-activity studies show that the sum of the parts does not equal the whole. ► NOSH-aspirin reduced tumor growth by 85% in mice bearing a colon cancer xenograft.