Notch-ligand expression by NALT dendritic cells regulates mucosal Th1- and Th2-type responses

► Nasal Ad-FL effectively up-regulates APC function by CD11c+ DCs in mucosal tissues. ► Nasal Ad-FL induces Notch ligand (L)-expressing CD11c+ DCs. ► Notch L-expressing DCs support the induction of Th1- and Th2-type cytokine responses.