Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms

► Novel transcript variants of Vwc2l were identified. ► Vwc2l isoforms were differentially expressed in mouse tissues. ► Vwc2l expression is associated with matrix mineralization in osteoblasts. ► Vwc2l promotes matrix mineralization in vitro. ► Addition of Vwc2l isoform proteins induces Osterix expression.