Increase of L-type Ca2+ current by protease-activated receptor 2 activation contributes to augmentation of spontaneous uterine contractility in pregnant rats

► PAR-2 agonists augment spontaneous myometrial contractility (SMC) in pregnant rat. ► Bay K 8644 (a Ca2+ channel activator) occluded the effect of PAR-2 agonists on SMC. ► PAR-2 agonists enhanced L-type Ca2+ currents in uterine myocyte in pregnant rat. ► This PAR-2 effect on L-type Ca2+ currents was mediated by PLC and PKC activation.